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Clozapine
- indication:For use in patients with treatment-resistant schizophrenia.
- pharmacologypharmacology:
- mechanism: Clozapine's antipsychotic action is likely mediated through a combination of antogistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves positive symptoms while 5-HT2A antagonism alleviates negative symptoms.
- toxicity: Clozapine carries a black-box warning for agranulocytosis.
- absorprion: Rapid and almost complete
- halflife: 8 hours (range 4-12 hours)
- roouteelimination: Approximately 50% of the administered dose is excreted in the urine and 30% in the feces.
- volumedistribution:
- clearance: