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Clobazam
- indication:For treatment and management of epilepsy and anxiety disorder.
- pharmacologypharmacology:
- mechanism: Clobazam binds at a distinct binding site associated with a Cl<sup>-</sup> ionopore at the GABA-A receptor, increasing the duration of time for which the Cl<sup>-</sup> ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is prolonged as a result.
- toxicity:
- absorprion: Bioavailability is 90%.
- halflife: 18 hours
- roouteelimination:
- volumedistribution:
- clearance: