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Mitomycin
- indication:For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder.
- pharmacologypharmacology:
- mechanism: Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
- toxicity: Oral, mouse: LD<sub>50</sub> = 23 mg/kg; Oral, rat: LD<sub>50</sub> = 30 mg/kg. Symptoms of overdose include nausea and vomiting.
- absorprion: Erratic.
- halflife: 8-48 min
- roouteelimination: Approximately 10% of a dose of mitomycin is excreted unchanged in the urine.
- volumedistribution:
- clearance: