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Indinavir
- indication:Indinavir is an antiretroviral drug for the treatment of HIV infection.
- pharmacologypharmacology:
- mechanism: Indinavir inhibits the HIV viral protease enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
- toxicity: Symptoms of overdose include myocardial infarction and angina pectoris.
- absorprion: Rapidly absorbed
- halflife: 1.8 (± 0.4) hours
- roouteelimination: Less than 20% of indinavir is excreted unchanged in the urine.
- volumedistribution:
- clearance: