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Cetrorelix
- indication:For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
- pharmacologypharmacology:
- mechanism: Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
- toxicity:
- absorprion: Rapidly absorbed following subcutaneous injection. The mean absolute bioavailability following subcutaneous administration to healthy female subjects is 85%.
- halflife: ~62.8 hours
- roouteelimination: Following subcutaneous administration of 10 mg cetrorelix to males and females, only unchanged cetrorelix was detected in urine.
- volumedistribution: * 1.16 L/kg
- clearance: * 1.28 ml/min·kg [adult healthy female with 3 mg single SC administration]