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Lutropin alfa
- indication:For treatment of female infertility
- pharmacologypharmacology:
- mechanism: Binds to the luteinizing hormone receptor which then activates adenylate cylcase through G protein mediation. Adenylate cyclase then activates many other pathways leading to steroid hormone production and other follicle maturation processes.
- toxicity:
- absorprion:
- halflife: 4.4 hours (mammalian reticulocytes, in vitro)
- roouteelimination: Total body clearance is approximately 2 to 3 L/h with less than 5 percent of the dose being excreted unchanged renally.
- volumedistribution: * 10 L
- clearance: * 2 – 3 L/h [healthy female following subcutaneous administration]