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Omalizumab
- indication:For treatment of asthma caused by allergies
- pharmacologypharmacology:
- mechanism: Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
- toxicity:
- absorprion:
- halflife: 26 days
- roouteelimination: Liver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile.
- volumedistribution: * 78 ± 32 mL/kg
- clearance: