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Glucagon recombinant
- indication:For treatment of severe hypoglycemia, also used in gastrointestinal imaging
- pharmacologypharmacology:
- mechanism: Glucagon binds the glucagon receptor which then initiates a dual signaling pathway using both adenylate cyclase activation and increased intracellular calcium. Glucagon receptors are found in the liver, kidney, brain and pancreatic islet cells. The glucagon mediated signals lead to an increase in insulin excretion
- toxicity:
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution: * 0.25 L/kg
- clearance: * 13.5 mL/min/kg [Adults with IV 1 mg]