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Leuprolide
- indication:For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
- pharmacologypharmacology:
- mechanism: Leuprolide binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.
- toxicity:
- absorprion:
- halflife: ~3 hours
- roouteelimination:
- volumedistribution: * 27 L [intravenous bolus administration to healthy male volunteers]
- clearance: * 8.34 L/h [healthy male receiving a 1-mg IV bolus]