For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.
The antiinflammatory effects of tenoxicam may result from the inhibition of the enzyme cycooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.
Oral absorption of tenoxicam is rapid and complete (absolute bioavailability 100%).
72 hours (range 59 to 74 hours)