For the treatment of serious infections caused by susceptible strains microorganisms.
The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.
The acute intravenous LD50 in the adult female mouse and rabbit was about 8.0 g/kg and greater than 1.0 g/kg, respectively. The acute intraperitoneal LD50 in the adult rat was greater than 10.0 g/kg.
The half-life after an intravenous dose is 41 to 59 minutes.
Approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period, resulting in high urinary concentrations. Cefoxitin passes into pleural and joint fluids and is detectable in antibacterial concentrations in bile.