| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2801974101018 | 197410101 | ZOCOR F.C.TAB 10MG/TAB ΒΤx10 | 0.73 | 0.77 | 01.06 |
| 05/2018 | 2801974102015 | 197410201 | ZOCOR F.C.TAB 20MG/TAB BT x 10 | 2.98 | 3.13 | 4.31 |
| 05/2018 | 2801974103012 | 197410301 | ZOCOR F.C.TAB 40MG/TAB BTx10 | 3.48 | 3.65 | 05.04 |
For the treatment of hypercholesterolemia.
The 6-membered lactone ring of simvastatin is hydrolyzed <i>in vivo</i> to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
3 hours
Following an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces.