| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802781101017 | 278110101 | REVLIMID CAPS 5MG/CAP Χάρτινη συσκευασία x 21 (σε BLISTERS PCTFE/PVC/ALU) 21 (σε BLISTERS PCTFE/PVC/ALU) | 3945.76 | 4004.95 | 4330.15 |
| 05/2018 | 2802781102014 | 278110201 | REVLIMID CAPS 10 MG/CAP Χάρτινη συσκευασία x 21 (σε BLISTERS PCTFE/PVC/ALU) 21 (σε BLISTERS PCTFE/PVC/ALU) | 4105.75 | 4167.34 | 4505.73 |
| 05/2018 | 2802781103011 | 278110301 | REVLIMID CAPS 15 MG/CAP Χάρτινη συσκευασία x 21 (σε BLISTERS PCTFE/PVC/ALU) 21 (σε BLISTERS PCTFE/PVC/ALU) | 4314.39 | 4379.11 | 4734.69 |
| 05/2018 | 2802781104018 | 278110401 | REVLIMID CAPS 25 MG/CAP Χάρτινη συσκευασία x 21 (σε BLISTERS PCTFE/PVC/ALU) 21 (σε BLISTERS PCTFE/PVC/ALU) | 4702.59 | 4773.13 | 5160.71 |
| 05/2018 | 2802781107019 | 278110701 | REVLIMID CAPS 20MG/CAP BT x21 (BLIST 3x7) σε BLISTERS (PVC/PCTFE/αλουμίνιο) | 4791.82 | 4863.70 | 5258.63 |
For the treatment of patients with transfusion-dependent anemia due to low- or intermediate- risk myelodysplastic syndromes associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.
The mechanism of action of lenalidomide remains to be fully characterized, however it has been demonstrated that lenalidomide inhibits the expression of cyclooxygenase-2 (COX-2), but not COX-1, in vitro. In vivo it induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity
The most frequently reported adverse events were related to blood and lymphatic system disorders, skin and subcutaneous tissue disorders, gastrointestinal disorders, and general disorders and administrative site conditions.
Rapidly absorbed following oral administration, with maximum plasma concentrations occurring between 0.625 and 1.5 hours post-dose. Co-administration with food does not alter the extent of absorption (AUC) but does reduce the maximal plasma concentration (C<sub>max</sub>) by 36%. The pharmacokinetic disposition of lenalidomide is linear.
3 hours
In healthy volunteers, approximately two-thirds of lenalidomide is eliminated unchanged through urinary excretion.