| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2800042601016 | 4260101 | PRIMPERAN INJ.SOL 10MG/2ML AMP BTX6AMPX2ML | 01.01 | 01.06 | 1.46 |
| 05/2018 | 2800042603010 | 4260301 | PRIMPERAN SYR 5MG/5ML FLX125ML (+ δοσιμετρική σύριγγα) | 0.92 | 0.97 | 1.34 |
| 05/2018 | 2800042603027 | 4260302 | PRIMPERAN SYR 5MG/5ML FLx200ML (+ δοσιμετρική σύριγγα) | 1.47 | 1.55 | 2.14 |
| 05/2018 | 2800042604024 | 4260402 | PRIMPERAN TAB 10MG/TAB BTx20 (BLIST 1x20) | 1.22 | 1.28 | 1.76 |
For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide's dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals.
Oral, mouse LD<sub>50</sub>: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Rapidly and well absorbed (oral bioavailability 80&plusmn;15.5%).
5-6 hr
Approximately 85% of the radioactivity of an orally administered dose appears in the urine within 72 hours.
* 4.4±0.65 L/kg
* 0.67 +/- 0.14 L/hr/kg [infants (0.9-5.4 months) with gastroesophageal reflux (GER)]