| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802711502044 | 271150204 | OXCARBAZEPINE/GENERICS F.C.TAB 300MG/TAB BTx50 (PVDC/PVC BLISTERS STRIPS) (PVDC/PVC BLISTERS STRIPS) | 4.38 | 4.59 | 6.33 |
| 05/2018 | 2802711503041 | 271150304 | OXCARBAZEPINE/GENERICS F.C.TAB 600MG/TAB BTx50 (PVDC/PVC BLISTERS STRIPS) (PVDC/PVC BLISTERS STRIPS) | 07.01 | 7.35 | 10.13 |
For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.
The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily through its 10-monohydroxy metabolite (MHD). In vitro studies indicate an MHD-induced blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neuronal membranes, inhibition of repetitive neuronal discharges, and diminution of propagation of synaptic impulses.
Isolated cases of overdose with oxcarbazepine have been reported. The maximum dose taken was approximately 24,000 mg. All patients recovered with symptomatic treatment.
Completely absorbed following oral administration. Food has no effect on the rate and extent of absorption of oxcarbazepine.
The half-life of the parent is about 2 hours, while the half-life of MHD is about 9 hours, so that MHD is responsible for most anti-epileptic activity.
Oxcarbazepine is cleared from the body mostly in the form of metabolites which are predominantly excreted by the kidneys. Fecal excretion accounts for less than 4% of the administered dose.
* 49 L