| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802960003019 | 296000301 | NEWZYPRA OR.DISP.TA 5MG/TAB BTx28 (σε blister) | 10.93 | 11.47 | 15.80 |
| 05/2018 | 2802960005013 | 296000501 | NEWZYPRA OR.DISP.TA 20MG/TAB BTx28 (σε blister) | 47.53 | 49.86 | 68.71 |
For the acute and maintenance treatment of schizophrenia and related psychotic disorders, as well as acute treatment of manic or mixed episodes of bipolar 1 disorder. Intramuscular olanzapine is indicated for the rapid control of agitated patients.
Olanzapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.
Symptoms of an overdose include tachycardia, agitation, dysarthria, decreased consciousness and coma. Death has been reported after an acute overdose of 0.45g, but also survival after an acute overdose of 1500g.
Well absorbed, with approximately 40% of the dose metabolized before reaching the systemic circulation.
21 to 54 hours
It is eliminated extensively by first pass metabolism, with approximately 40% of the dose metabolized before reaching the systemic circulation. Following a single oral dose of 14C labeled olanzapine, 7% of the dose of olanzapine was recovered in the urine as unchanged drug, indicating that olanzapine is highly metabolized.
* 1000 L
* 12 to 47 L/h