| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802820901011 | 282090101 | NEVANAC EY.DRO.SUS 1MG/ML BT x 1 BOTTLE (LDPE) x 5 ML x 5 ML | 11.02 | 11.56 | 15.92 |
| 05/2018 | 2802820902018 | 282090201 | NEVANAC EY.DRO.SUS 3MG/ML BT x 1 BOTTLE (LDPE) x 3 ML x 3 ML | 16.56 | 17.37 | 23.93 |
For the treatment of pain and inflammation associated with cataract surgery.
Nepafenac is a prodrug. After penetrating the cornea, nepafenac undergoes rapid bioactivation to amfenac, which is a potent NSAID that uniformly inhibits the COX1 and COX2 activity.
Ocularly applied non-steroidal anti-inflammatory drugs may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery.
Nepafenac rapidly cross the cornea (6 times faster than diclofenac in vitro).
After oral administration of 14C-nepafenac to healthy volunteers, urinary excretion was found to be the major route of radioactivity elimination, accounting for approximately 85% of the dose, while fecal excretion represented approximately 6% of the dose. Nepafenac (prodrug) and amfenac (active compound) were not quantifiable in the urine.