| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2801193502016 | 119350201 | NAPROSYN SUPP 500MG/SUP ΒΤx6 | 1.39 | 1.46 | 02.01 |
| 05/2018 | 2801193504027 | 119350402 | NAPROSYN TAB 500MG/TAB ΒΤΧ30 (BLIST 3 X 10) | 4.59 | 4.81 | 6.63 |
| 05/2018 | 2801193507011 | 119350701 | NAPROSYN GR.TAB 500MG/TAB BTx28(BLIST2x14) | 4.64 | 4.87 | 6.71 |
For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.
The mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
ORAL (LD<sub>50</sub>): Acute: 248 mg/kg [Rat]. 360 mg/kg [Mouse]. Symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting.
Naproxen itself is rapidly and completely absorbed from the GI tract with an in vivo bioavailability of 95%. Although naproxen itself is well absorbed, the sodium salt form is more rapidly absorbed resulting in higher peak plasma levels for a given dose. Food causes a slight decrease in the rate absorption.
The observed terminal elimination half-life is approximately 15 hours.