| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802545903017 | 254590301 | METALYSE PS.INJ.SOL 10000 IU (50MG)/VIAL 1VIAL+1PF.SYR.x10ML | 659.86 | 669.76 | 759.64 |
For treatment of myocardial infarction and lysis of intracoronary emboli
Tenecteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
1.9 hours (mammalian reticulocytes, in vitro) >20 hours (yeast, in vivo) >10 hours (Escherichia coli, in vivo)
* 99 - 119 mL/min [acute myocardial infarction patients]