| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2800586702019 | 58670201 | MEDROL TAB 4MG/TAB ΒΤx50 (BLIST 5x10) | 2.94 | 03.08 | 4.25 |
| 05/2018 | 2800586703016 | 58670301 | MEDROL TAB 16MG/TAB ΒΤx14 (BLIST 2x7) | 4.51 | 4.73 | 6.52 |
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
LD<sub>50</sub>=2000 mg/kg (orally in rat)
Oral bioavailability 80-99%
1-3 hours