| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802040001010 | 204000101 | MAVITALON TAB 60MG/TAB ΒΤΧ30(BLIST 2X15) | 1.46 | 1.53 | 2.11 |
For the treatment of Hypertension
Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
LD<sub>50</sub>=740mg/kg (orally in mice)
Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.
3.0 - 4.5 hours