| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2801000001015 | 100000101 | LEPONEX TAB 25MG/TAB BTx50 | 2.85 | 2.99 | 4.12 |
| 05/2018 | 2801000002012 | 100000201 | LEPONEX TAB 100MG/TAB BTx50 (BLIST5x10) | 10.33 | 10.84 | 14.94 |
For use in patients with treatment-resistant schizophrenia.
Clozapine's antipsychotic action is likely mediated through a combination of antogistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves positive symptoms while 5-HT2A antagonism alleviates negative symptoms.
Clozapine carries a black-box warning for agranulocytosis.
Rapid and almost complete
8 hours (range 4-12 hours)
Approximately 50% of the administered dose is excreted in the urine and 30% in the feces.