| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802018101018 | 201810101 | LAMICTAL TAB 25MG ΒΤx30 | 3.12 | 3.27 | 4.51 |
| 05/2018 | 2802018102015 | 201810201 | LAMICTAL TAB 50MG/TAB ΒΤ x 30 | 4.84 | 05.08 | 7.00 |
| 05/2018 | 2802018103012 | 201810301 | LAMICTAL TAB 100MG/TAB ΒΤx30 (BLIST 3 x 10) | 5.41 | 5.68 | 7.82 |
| 05/2018 | 2802018104019 | 201810401 | LAMICTAL CH/DIS.TAB 5MG/TAB BTx30 (BLIST 3x10) | 1.62 | 1.70 | 2.34 |
| 05/2018 | 2802018107010 | 201810701 | LAMICTAL TAB 200MG/TAB BTx30 (BLIST 3x10) | 13.78 | 14.45 | 19.92 |
| 05/2018 | 2802018110010 | 201811001 | LAMICTAL CH/DIS.TAB 2MG/TAB BTx1FL x30 TABS | 1.59 | 1.66 | 2.29 |
For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
One proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. <i>in vitro</i> pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels and/or calcium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate). Studies on lamotrigine show binding to sodium channels similar to local anesthetics.
LD<sub>50</sub>=250 (mg/kg) (in rat, mice); LD<sub>50</sub>>640 orally (mg/kg) (in rat, mice) (Sawyer). Symptoms of overdose include decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, and rolling eyeballs.
98%
25 +/- 10 hours (healthy individuals); 42.9 hours (chronic renal failure)
* 0.9 to 1.3 L/kg
* Apparent plasma cl=0.44 mL/min/kg [healthy volunteers taking single-dose LAMICTAL] * Apparent plasma cl=0.58 mL/min/kg [healthy volunteers taking multiple-dose LAMICTAL] * Apparent plasma cl=0.30 mL/min/kg [healthy volunteers taking valproate and single-dose LAMICTAL] * Apparent plasma cl=0.18 mL/min/kg [healthy volunteers taking valproate and multiple-dose LAMICTAL] * Apparent plasma cl=1.1 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and single-dose LAMICTAL] * Apparent plasma cl=1.12 mL/min/kg [Patients with epilepsy taking carbamazepine, phenytoin, phenobarbital, or primidone plus valproate and multiple-dose LAMICTAL]