| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2800501906010 | 50190601 | ISOPTIN PR.TAB 240MG/TAB BTx20 | 2.90 | 03.04 | 4.19 |
| 05/2018 | 2800501907017 | 50190701 | ISOPTIN F.C.TAB 40MG/TAB BTx30(BLIST3x10) | 0.79 | 0.83 | 1.14 |
| 05/2018 | 2800501908014 | 50190801 | ISOPTIN F.C.TAB 80MG/TAB BTx20(BLIST2x10) | 0.99 | 01.04 | 1.43 |
| 05/2018 | 2800501909011 | 50190901 | ISOPTIN F.C.TAB 120MG/TAB BTx20(BLIST2x10) | 1.28 | 1.34 | 1.84 |
For the treatment of hypertension, angina, and cluster headache prophylaxis.
Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known.
LD<sub>50</sub>=8 mg/kg (i.v. in mice)
90%
2.8-7.4 hours
Approximately 70% of an administered dose is excreted as metabolites in the urine and 16% or more in the feces within 5 days. About 3% to 4% is excreted in the urine as unchanged drug.