| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2802287403011 | 228740301 | INVIRASE F.C.TAB 500 mg/TAB FL x 120 | 189.52 | 198.81 | 240.24 |
For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
Saquinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Probably experience pain in the throat
Absolute bioavailability averages 4%
In vitro studies using human liver microsomes have shown that the metabolism of saquinavir is cytochrome P450 mediated with the specific isoenzyme, CYP3A4, responsible for more than 90% of the hepatic metabolism. Only 1% of saquinavir is excreted in the urine, so the impact of renal impairment on saquinavir elimination should be minimal.
* 700 L
* 1.14 L/h/kg [Healthy volunteers receiving IV doses of 6, 36, and 72 mg]