| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2803132701016 | 313270101 | HIREMON INJ.EM.IN 10MG/ML BTx1 GLASS VIAL x 100 ML | 4.47 | 4.69 | 6.47 |
| 05/2018 | 2803132701054 | 313270105 | HIREMON INJ.EM.IN 10MG/ML BTx1 GLASS VIAL x 50 ML | 2.10 | 2.20 | 03.03 |
| 05/2018 | 2803132701108 | 313270110 | HIREMON INJ.EM.IN 10MG/ML BTx5 GLASS VIAL x 20 ML | 4.19 | 4.40 | 06.06 |
| 05/2018 | 2803132702013 | 313270201 | HIREMON INJ.EM.IN 20MG/ML BTx1 GLASS VIAL x 50 ML | 5.41 | 5.67 | 7.81 |
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors.
Overdosage may increase pharmacologic and adverse effects or cause death. <p>IV LD<sub>50</sub>=53 mg/kg (mice), 42 mg/kg (rats). Oral LD<sub>50</sub> (as a solution in soybean oil)=1230 mg/kg (mice), 600 mg/kg (rats)</p>
Rapid - time to onset of unconsciousness is 15-30 seconds, due to rapid distribution from plasma to the CNS. Distribution is so rapid that peak plasma concentrations cannot be readily measured. Duration of action is 5-10 minutes.
Initial distribution phase t<sub>1/2&alpha;</sub>=1.8-9.5 minutes. Second redistirubtion phase t<sub>1/2&beta;</sub>=21-70 minutes. Terminal elimination phase t<sub>1/2&gamma;</sub>=1.5-31 hours.
It is chiefly eliminated by hepatic conjugation to inactive metabolites which are excreted by the kidney.
* 60 L/kg [healthy adults]
* 23 - 50 mL/kg/min * 1.6 - 3.4 L/min [70 Kg adults]