| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2801264703038 | 126470303 | HIPNOSEDON F.C.TAB 1MG/TAB BTx30 (BLIST 3x10) | 1.83 | 1.92 | 2.65 |
For short-term treatment of severe insomnias, that are not responsive to other hypnotics.
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
50% (suppository) and 64-77% (oral)
18-26 hours