| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2803071201028 | 307120102 | FLIXAN TAB 5MG/TAB BTx3 (σε κυψέλη PA/AL/PVC-Aluminium) (σε κυψέλη PA/AL/PVC-Aluminium) | 2.57 | 2.70 | 3.72 |
| 05/2018 | 2803071202025 | 307120202 | FLIXAN TAB 10MG/TAB BTx3 (σε κυψέλη PA/AL/PVC-Aluminium) (σε κυψέλη PA/AL/PVC-Aluminium) | 4.44 | 4.66 | 6.42 |
| 05/2018 | 2803071203022 | 307120302 | FLIXAN OR.DISP.TA 5MG/TAB BTx3 (σε κυψέλη PA/AL/PVC-Aluminium) (σε κυψέλη PA/AL/PVC-Aluminium) | 2.57 | 2.70 | 3.72 |
| 05/2018 | 2803071204029 | 307120402 | FLIXAN OR.DISP.TA 10MG/TAB BTx3 (σε κυψέλη PA/AL/PVC-Aluminium) (σε κυψέλη PA/AL/PVC-Aluminium) | 4.14 | 4.34 | 5.98 |
For treatment of acute migraine attacks with or without aura.
Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves to inhibit both dural vasodilation and inflammation; (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism.
Symptoms of overdose include dizziness, fainting, heart and blood vessel problems, high blood pressure, loss of bowel and bladder control, slow heartbeat, and vomiting.
Rapid following oral administration. Bioavailability is 45%. Food has no effect on the bioavailability of rizatriptan. However, administering rizatriptan with food will delay by 1 hour the time to reach peak plasma concentration. The rate of absorption is not affected by the presence of a migraine attack.
2-3 hours
Approximately 14% of an oral dose is excreted in urine as unchanged rizatriptan while 51% is excreted as indole acetic acid metabolite, indicating substantial first pass metabolism.
* 140 L [male] * 110 L [female]