| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2800019102010 | 1910201 | DAONIL TAB 5MG/TAB ΒΤx30(BLIST 2x15) | 1.35 | 1.42 | 1.96 |
| 05/2018 | 2800019102041 | 1910204 | DAONIL TAB 5MG/TAB BTx 30 (BLIST1x30) | 1.18 | 1.24 | 1.71 |
Indicated as an adjunct to diet to lower the blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.
Sulfonylureas such as glibenclamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Oral rat LD<sub>50</sub>: > 20,000 mg/kg. Oral mouse LD<sub>50</sub>: 3250 mg/kg.
Significant absorption within 1 hour and peak plasma levels are reached within 4 hours.
10 hours
Glyburide is excreted as metabolites in the bile and urine, approximately 50% by each route. This dual excretory pathway is qualitatively different from that of other sulfonylureas, which are excreted primarily in the urine.