| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2801669401010 | 166940101 | CALMOFLORINE TAB 50MG/TAB ΒΤΧ30 | 1.17 | 1.23 | 1.70 |
| 05/2018 | 2801669402024 | 166940202 | CALMOFLORINE TAB 200MG/TAB ΒΤΧ15 | 1.28 | 1.34 | 1.84 |
Sulpiride is indicated for the treatment of schizophrenia.
In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.
Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
6 to 8 hours