AZATHIOPRINE-PHARMACHEMIECopy

• DRUGBANK - Azathioprine
• indication:

  For use in rheumatoid arthritis, preventing renal transplant rejection, Crohn's disease, and colitis.

• pharmacology:

• mechanism:

  Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. Its mechanism of action is likely due to incorporation of thiopurine analogues into the DNA structure, causing chain termination and cytotoxicity.

• toxicity:

  The oral LD<sub>50</sub> for single doses of azathioprine in mice and rats are 2500 mg/kg and 400 mg/kg, respectively. Very large doses of this antimetabolite may lead to marrow hypoplasia, bleeding, infection, and death.

• absorprion:

  Well absorbed following oral administration.

• halflife:

  Approximately 5 hours for the unchanged drug and its metabolites.

• roouteelimination:

• volumedistribution:

• clearance: