ALMOGRANCopy

• DRUGBANK - Almotriptan
• indication:

  For the treatment of acute migraine headache in adults

• pharmacology:

• mechanism:

  Almotriptan binds with high affinity to human 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> receptors leading to cranial blood vessel constriction.

• toxicity:

• absorprion:

• halflife:

  3-4 hours

• roouteelimination:

  Almotriptan is eliminated primarily by renal excretion (about 75% of the oral dose), with approximately 40% of an administered dose excreted unchanged in urine. Approximately 13% of the administered dose is excreted via feces, both unchanged and metabolized.

• volumedistribution:

  * 180 to 200 L

• clearance:

  * 57 L/h [healthy] * 34.2 L/h [moderate renal impairment (creatinine clearance between 31 and 71 mL/min)] * 9.8 L/h [severe renal impairment (creatinine clearance between 10 and 30 mL/min)]