| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2801265401018 | 126540101 | ALDACTONE F.C.TAB 25MG/TAB ΒT x 20 | 1.35 | 1.42 | 1.96 |
| 05/2018 | 2801265402015 | 126540201 | ALDACTONE F.C.TAB 100MG/TAB ΒΤ x 20 | 3.58 | 3.76 | 5.19 |
Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.
Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule.
The oral LD<sub>50</sub> of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.
Fairly rapidly absorbed from the gastrointestinal tract. Food increases the bioavailability of unmetabolized spironolactone by almost 100%.
10 minutes
The metabolites are excreted primarily in the urine and secondarily in bile.