| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2803051101010 | 305110101 | AFLOXOL EF.TAB 200MG/TAB [BTx7 (1 strip x7) σε STRIP ALU/PE] | 07.04 | 7.39 | 10.19 |
| 05/2018 | 2803051101027 | 305110102 | AFLOXOL EF.TAB 200MG/TAB [BTx28 (7 strip x4)] σε STRIP ALU/PE | 24.80 | 26.01 | 35.84 |
| 05/2018 | 2803051102017 | 305110201 | AFLOXOL SOL.INF 2MG/ML BTx1 BAG x 100ML | 4.43 | 4.65 | 6.41 |
| 05/2018 | 2803051102024 | 305110202 | AFLOXOL SOL.INF 2MG/ML BTx10 BAGS x 100ML | 44.37 | 46.54 | 64.13 |
For the treatment of fungal infections.
Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Symptoms of overdose include hallucinations and paranoid behavior.
90%
30 hours (range 20-50 hours)
In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug.
* 0.23 mL/min/Kg [adults] * 0.18 mL/min/Kg [In premature newborns within 36 hours of birth] * 0.22 mL/min/Kg [In premature newborns 6 days old] * 0.33 mL/min/Kg [In premature newborns 12 days old] * 0.4 mL/min/kg [9 Months-13 yearsreceiving single-oral 2 mg/kg] * 0.51 mL/min/Kg [9 Months-13 yearsreceiving single-oral 8 mg/kg] * 0.49 mL/min/Kg [5-15 yearsreceiving multiple IV 2 mg/kg] * 0.59 mL/min/Kg [5-15 yearsreceiving multiple IV 4 mg/kg] * 0.66 mL/min/Kg [5-15 yearsreceiving multiple IV 8 mg/kg]