| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2800332505017 | 33250501 | AEROLIN AER.MD.INH 100MCG/DOSE ΣΥΣΚΕΥΗ 200 ΔΟΣΕΙΣ (17g) (17g) | 1.52 | 1.60 | 2.20 |
| 05/2018 | 2800332514019 | 33251401 | AEROLIN PD.INH.MD 200MCG/DOSE Ταινια x60 BLISTERS AL σε πλαστικη συσκευή DISKUS AL σε πλαστικη συσκευή DISKUS | 3.57 | 3.75 | 5.17 |
| 05/2018 | 2800332516020 | 33251602 | AEROLIN NEBULES INH.SOL.N 2.5mg/2.5ML AMP (SD) BTx20(AMP.ΠΛ.x2,5 ML (2 STRIPS x10) (2 STRIPS x10) | 2.62 | 2.75 | 3.79 |
| 05/2018 | 2800332517027 | 33251702 | AEROLIN NEBULES INH.SOL.N 5mg/2,5ML AMP (SD) BTx20 [AMP.ΠΛ.x2,5 ML (2 STRIPSx10)] (2 STRIPSx10)] | 3.79 | 3.98 | 5.48 |
For symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD.
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance.
LD<sub>50</sub>=1100 mg/kg (orally in mice)
Systemic absorption is rapid following aerosol administration.
1.6 hours
Approximately 72% of the inhaled dose is excreted in the urine within 24 hours, 28% as unchanged drug and 44% as metabolite.