| Ημερομηνία | barcode | code | περιεχομενο | τιμή παραγωγός | χονδρική | λιανική |
|---|---|---|---|---|---|---|
| 05/2018 | 2803069502021 | 306950202 | ADASUVE INH.PD.DOS 9,1MG/DOSE BTx1 INHALER | 67.02 | 70.31 | 89.43 |
For the management of the manifestations of psychotic disorders such as schizophrenia
Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
LD<sub>50</sub>=65 mg/kg (Orally in mice)
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Oral-4 hours
Metabolites are excreted in the urine in the form of conjugates and in the feces unconjugated.