For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Along with its actions as an antagonist at H<sub>1</sub>-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Symptoms of overdose include drowsiness and anticholinergic effects. LD<sub>50</sub>=mg/kg (orally in rat).
Well absorbed
6 hours