For the treatment of mild to moderate active Crohn's disease. Also for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis.
The exact mechanism of action of budesonide in the treatment of Crohn's disease is not fully understood. However, being a glucocorticosteroid, budesonide has a high local anti-inflammatory effect.
Single oral doses of 200 and 400 mg/kg were lethal in female and male mice, respectively. The signs of acute toxicity were decreased motor activity, piloerection and generalized edema.
Absorption is complete following oral administration.
2.0 and 3.6 hours
Budesonide is excreted in urine and feces in the form of metabolites.
* 3 L/kg [asthmatic children 4 to 6 years of age]
* 0.5 L/min [Athmatic children 4 to 6 years of age]