For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
LD<sub>50</sub>=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness
Well absorbed from gastrointestinal tract.
3.35 (+/- 0.66) hours
Less than 30% of the dose is excreted in the urine as rifampin or metabolites.
* 0.19 +/- 0.06 L/hr/kg [300 mg IV] * 0.14 +/- 0.03 L/hr/kg [600 mg IV]